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";s:4:"text";s:24907:"2800 Plymouth Road Follow procedures outlined in. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. x��Zmo�� ���'X+�(�X�$�w[����i��[���Z>EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� The same authors ( Smith et al. Pages 83. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. Mouse rotavirus (MRV) is a group A rotavirus that replicates in the villus epithelial cells of the small intestine. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … Both cases require work in higher biosafety level containments, additional screening methods and special guidelines for the handling and restraint of such animals. guideline housing mouse scientific institution SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to No. Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. These rodents are social species and should be housed together, unless scientifically justified for individual housing. … endobj The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design Debby Laukens, ... the genetic history of mutant mice is often ambiguous when mice are shared between institutions (Sellers et al. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. endobj Management of Fighting Mice . Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. ACUO is a unit of the U-M Office of Research: ULAM is a unit of the Medical School Office of Research: Copy Generated on: January 25, 2021, 5:38 am, Guidelines for Documenting Scientific Justification for Exceeding Cage Densities, Maximum Housing Densities for Rat and Mouse Cages, Guidelines on Anesthesia and Analgesia in Ruminants, Guidelines on Administration of Substances to Laboratory Animals, Guidelines on Use of Streptozotocin in Rodents, Guidelines on Adjuvant Use in Rabbits Rats and Mice, The Regents of the University of Michigan. This preview shows page 45 - 48 out of 83 pages. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Effect of the Extract on the Intestinal Transit of Charcoal Meal in Mice. %���� Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 in. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. %PDF-1.5 Not a departure. Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. This does not apply to: Littermates that have been cage mates since birth. given to mice infected with human-pathogenic or zoonotic agents or genetically modified mice that har-bour receptors for human pathogens. The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). While we have successfully managed many mouse colonies over the years using this system, we are uncertain that the cage space guidelines described in the 8th edition of the Guide allows trio-breeding schemes in standard cages. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. OLAW FAQ G10, Guide pp 6-7. Ann Arbor, MI 48109 The IACUC acknowledges that some specialized genetically modified lines may require more than 2 adults and 1 litter in the breeding cage to facilitate adequate production. It is suggested that the housing of laboratory rodents should be improved by the use of … Delayed weaning (weaning at >21 days) requires prior IACUC approval. Some strains are more aggressive than others, and fight regardless of the age at combination. Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE GUIDELINES FOR RATS AND MICE . Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Unit for Laboratory Animal Medicine (ULAM) The normal total cholesterol level is 26.0-82.4 mg/dl. Guidelines for Transgenic Research. <> Ventilated cages were designed to prevent the accumulation of NH 2 0 obj Additional floor space may be required in order to ensure animal well-being. the draft guidelines for the housing of mice in scientific institutions. The most common breeding scheme for mice at our AAALAC accredited institution is trio-breeding. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� Tumour However, rats and mice are social animals; and individual housing constitutes a stressful situation. Basic requirements for good rodent housing and husbandry are given in the table below. Animal Care & Use Office (ACUO) Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. The NC3Rs have led a data crowdsourcing project, which estimated the prevalence of aggression in UK facilities as approximately 15 in every 1,000 mice. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. <>>> 3.5. 䍫�����Q1Md:UdVDJ��*� For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. Group-house weaned males with their littermates only. These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. 1 0 obj 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. Deviation from Guide should statement according to IACUC-approved: Scientific justification Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. This review should begin no later than October 1, 2020. Purpose. New arrival mice. Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. Do not recombine adult male mice (older than 5 weeks) that have been separated. Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. endobj Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 House males individually in these circumstances, or with females, if intending to breed. In general, the housing temperature for laboratory mice in research facilities is between 20–26 °C [6, 7] or 18–23 °C ; while the thermoneutral … These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. OpenURL . Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions … Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or ulam-questions@umich.edu. 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