";s:4:"text";s:25396:"BMC Neurosci 2:11. <>stream endobj The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein. Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus). Additionally, an intronic point deletion in Gabra2, which arose sometime between the early 1970's and 1990's, results in decreased transcript and protein expression of this chloride channel component in the brain. The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. A naturally occurring deletion in nicotinamide nucleotide transhydrogenase (Nnt) exons 7-11 occurred in C57BL/6J sometime prior to 1984. Oxidative damage-induced inflammation initiates age-related macular degeneration. Antibody-deficient mice overcome obstacles to efficacy testing of biologics Structure of EMD Serono's bifunctional immune-oncology therapeutic M7824, from Lan et al.3 Immunogenicity can obscure efficacy in early preclinical research Biologic drugs such as monoclonal antibodies or RNA therapies can trigger immune reactions (immunogenicity) upon treatment. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. H��Wks�H��_�_���EUH0�l\�lmu�܋Fj��_��v�����PSiK��x@��.^Ug����뙻��Dlq��?lx����E�z^.ăzz����w݀���{~u��&����p�S钌ɫ�F�Jԝl�#=W�� �Γ�e����F��:.쇒%.\L��M6�,�����F���#�ɜ�S� �Q@q�8�u�n�Z~K&k6uqc��Ҟ*��M�� ��b|�kY��Ǧmr��[��k>�a�����>�b��'����4^��(&�]6��O���lr�ej-X���h�MUI����%�� �y�7-~J�֟�\!d'��s���ل��u�����A(����KQ�Zt�Q�t(�8s�4H4�^��Qۍ����]*�7g{�LI�N��&%�r(�9F:B�x�G��+o�r[��w��k>f��ވ#�������`��Ԫ)�F�U���V����ߺA�O��pϼ�I�l�켘R��B�. Metabolism 47(11):1354-9, Champy MF; Selloum M; Zeitler V; Caradec C; Jung B; Rousseau S; Pouilly L; Sorg T; Auwerx J. The wild-type C variant, coding for proline, is found in 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, A/J, BALB/c, CAST/EiJ ,NZW, LP/J, NOD/ShiLtJ, PWK/PhJ, WSB/EiJ, Mus caroli, M. spretus, M. musculus, and M. poschiavinus. These transactions are payable in U.S. currency within the granted terms. 1990. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805, Smith RS; Roderick TH; Sundberg JP. It is near a spice acceptor site and causes a substantial decrease in expression at the mRNA and protein levels in homozygous brain, with additional decreases in Gabra1, Gabra3, and Gabra5 transcripts in striatum This allele can be phenoytpically reversed entirely by the correction of this intronic point deletion (see, Black BL; Croom J; Eisen EJ; Petro AE; Edwards CL; Surwit RS. x�S�*�*T0T0 B�����i������ yS& To NIH in 1951 from The Jackson Laboratory at F32. Bioz Stars score: 92/100, based on 1 PubMed citations. <>>>/BBox[0 0 585 783]/Length 114>>stream Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). When using B6 mice it is very important to reference the full nomenclature that indicates its provenance and vendor code (eg, C57BL/6NTac from Taconic and C57BL/6J from The Jackson Laboratory). This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age. endstream Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. 6 0 obj One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and it's commonly used as the genetic background for transgenic mouse models. endobj endobj One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. A second C to T transition changes a proline codon in the DBA/2J allele to leucine codon in the C57BL/6J allele, and would likely change secondary structure of the peptide and thus ligand affinity. A G to A conversion within a cryptic splice site results in the preferential incorporation of a pseudo-exon, containing an in-frame stop codon as the second codon, into the transcript. 2014. application/pdf x�+� � | 1998. Th ey are safe, reliable, economical, effi cient, and ensure that Proc Natl Acad Sci U S A 91(12):5667-71, Welkos SL; Keener TJ; Gibbs PH. endstream <>>>/BBox[0 0 585 783]/Length 114>>stream Watch Video. Enter your email if you are happy for us to connect and reachout to you with more questions. <>stream Bone 18(5):397-403, Beamer WG; Shultz KL; Churchill GA; Frankel WN; Baylink DJ; Rosen CJ; Donahue LR. 1994. B6.Cg-Tg(Alb-Cre)21Mgn/J. Infection with the helminth Schistosoma mansoni results in hepatointestinal granulomatous inflammation mediated by CD4 T cells directed against parasite eggs. The C57BL/6 inbred mouse (B6) is the most commonly used research strain. <>stream Neuroscience 122(2):551-61, Mekada K; Abe K; Murakami A; Nakamura S; Nakata H; Moriwaki K; Obata Y; Yoshiki A. <>>>/BBox[0 0 585 783]/Length 114>>stream Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. The conditional Stat3 knockout mice (B6.129S1-Stat3tm1Xyfu /J), Rosa26-LSL-tdTomato (B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze /J), and Rosa26-LSL-DTA (Gt(ROSA)26Sortm1(DTA)Lky /J) were obtained from The Jackson Laboratory (Bar Harbour, ME). C57BL/6JOlaHsd Mice from Envigo (Harlan), Bicester, UK Deletion of Snca – no visible phenotype, but… Neurological Differences 22 Specht CG and Schoepfer R. 2001. More than 11,000 strains of mice are available from The Jackson Laboratory. We are working on improving the JAX Mice search. If you are interested in these mice or willing to disclose your mouse … Hear Res 93(1-2):181-7, Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. endobj Mamm Genome 19(5):318-31, Drake TA; Schadt E; Hannani K; Kabo JM; Krass K; Colinayo V; Greaser LE 3rd; Goldin J; Lusis AJ. These mice are on a congenic C57/BL genetic background. endstream Because homozygotes exhibit serious physical defects, such as vascular defects, polychromasia, kidney defects and palate bone fusion abnormalities, Sgpl1 +/+ and Sgpl1 ‐/‐ mice were not used to carry out animal experiments. 20 0 obj B6;129P2- Il2tm1Hor (original publication) 4-9 wks Progressive Yes B6.129P2-Il2tm1Hor/J pre & post wean loss, 10-25 weeks Progressive Yes C.129P2(B6)-Il2tm1Hor/J 3-5 wks None Yes Schorle H et al. Differences in susceptibility of inbred mice to Bacillus anthracis. Many inbred mouse strains have an exon 9 to 11 deletion, resulting in a null allele and susceptibility to myxoviruses, including: A/J, ABP/Le, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BL/KsJ, C57L/J, C58/J, DA/HuSn, DBA/2J, FSB/GnEi, FVB/NJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BINJ, P/J, PL/J, RIIIS/J, RF/J, SEA/GnJ, SEC1/ReJ, SJL/J, ST/bJ, TS1/A, TW1/A. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. This strain is the most well characterized, the first to have its’ entire genome sequenced, and is the genetic background strai . To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. Effects of atherogenic diet consumption on lipoproteins in mouse strains C57BL/6 and C3H. J Immunol 129(4):1530-3, Smith BK; Andrews PK; West DB. J Lipid Res 31(5):859-69, Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. C57BL/6J was the DNA source for the international collaboration that generated the first high quality draft sequence of the mouse genome. x�S�*�*T0T0 B�����i������ y\' 8 0 obj C57BL/6J is the most widely used inbred strain. The Jackson Laboratory (JAX)® advocates adherence to the mouse strain nomenclature guidelines as described by the International Committee on Standardized Genetic Nomenclature for Mice. 2004. Species: Mouse Genes: APOE Modification: APOE: Knock-In Disease Relevance: Alzheimer's Disease Strain Name: B6(SJL)-ApoE tm1.1(APOE*4)Adiuj /J Genetic Background: C57BL/6J Availability: The Jackson Laboratory, Stock # 027894; Live APOE4 knock-in mice express a humanized APOE4 allele from the endogenous ApoE locus. The Mx1r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. endobj C57BL/6J mice are also commonly used in the production of transgenic mice. An efficient SNP system for mouse genome scanning and elucidating strain relationships. Transgenic Res 20(3):481-9. Histol Histopathol 15(4):1087-92, Chen J; Astle CM; Harrison DE. 4 The Jackson Laboratory Breeding performance of laboratory mice can be affected by many factors, including the following: • Birth defects in the pups. 13 0 obj The approximate age of mouse pups can be determined by their physical attributes during the irst two weeks of life. This allele encodes a high affinity, relatively heat stabile, 95 kDa receptor. The JAX Synteny Browser for mouse-human comparative genomics. endobj default Examples of the developmental stages of albino, agouti, and black pups are shown. In vitro analysis demonstrates that the resulting truncated protein, which lacks several conserved C-terminal motifs, has less than 1% enzyme activity when compared to control C3H/HeJ mice. Genes Dev 7(3):454-67, Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. Susceptibility alleles do not produce the protein (J:8273). BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Other characteristics include: 1) a high susceptibility to diet-induced obesity, type 2 diabetes, and atherosclerosis; 2) a high incidence of microphthalmia and other associated eye abnormalities; 3) resistance to audiogenic seizures; 4) low bone density; 5) hereditary hydrocephalus (early reports indicate 1 - 4 %); 6) portosystemic shunts (~5%); 7) hairloss associated with overgrooming; 8) a preference for alcohol and morphine; 9) late-onset hearing loss; 10) increased incidence of hydrocephalus and malocclusion and 11) spontaneous calcaneal luxation in 1% of aged males beginning at 6-8 months of age, resulting in ankylosing enthesopathy of that tarsal joint. x�+� � | This allele contains a stretch of 17,814 bp missing between exons 6 and 12. Am J Physiol 262(6 Pt 2):R1025-32, Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 1992. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Study-ready aged C57BL/6J males and females between 25 - 90 weeks of age available for order. The following inbred strains are homozygous for the recessive QTL, Micrl. 3.1 SOURCES OF LABORATORY MICE. Genome Res 14(9):1806-11, Roberts JE; Watters JW; Ballard JD; Dietrich WF. Come back soon for exciting changes. Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1r allele. Others have subsequently identified further SNP differences between sublines of C57BL/6 (Mekada et al., 2009, Zurita et al., 2010). The Jackson Laboratory b6 sjl ptprca pepcb boyj mice B6 Sjl Ptprca Pepcb Boyj Mice, supplied by The Jackson Laboratory, used in various techniques. x�%�A�@�}O�(��'.�r�^���� The hybrid mice are heterozygous genetically and tend to serve as a background for some deleterious mutations. The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research.Laboratory mice are usually of the species Mus musculus.They are the most commonly used mammalian research model and are used for research in genetics, psychology, medicine and other scientific disciplines. J Lipid Res 36(7):1522-32, Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. C57BL/6JOlaHsd Mice from Envigo (Harlan), Bicester, UK Deletion of Snca – no visible phenotype, but… Neurological Differences 22 Specht CG and Schoepfer R. 2001. xmp.iid:c31c0f8a-1532-ed4d-a998-9ccad6f57fa8 Toggle menubar. The Genome of C57BL/6J “Eve”, the Mother of the Laboratory Mouse Genome Reference Strain. This strain is available from some international Charles River (CR) breeding facilities in Japan and/or Europe. They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness. 23 0 obj endstream endstream Developed by C.C. Dietary obesity in nine inbred mouse strains. Lipids 28(7):599-605, O'Malley J; Matesic LE; Zink MC; Strandberg JD; Mooney ML; De Maio A; Reeves RH. This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. Physiol Genomics 5(4):205-15, Fontaine DA; Davis DB. The Jackson Laboratory’s Mission 4 Performing Research Investigating genetics and biology of human disease Providing Resources JAX® Mice Clinical & Research Services, bioinformatics data, technical publications and more… (2)The Jackson Laboratory, Bar Harbor, ME, USA. endobj 2000. x�%�A�@�}O�(��'.�r�^���� Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings. <>stream endstream ZERO BIAS - scores, article reviews, protocol conditions and more J Neurophysiol 84(5):2484-93, Nishina PM; Verstuyft J; Paigen B. 2020-02-06T13:32:01+05:30 Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Mice derived from the original C57BL/6J: C57BL/ 6JArc, C57BL/6JfromThe Jackson Lab and C57BL/6J Mutation causes C57BL/6J strain-specific defect in neutrophil recruitment 129P2/OlaHsd strains and allows for recovery from viremia and in. 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New Quantitive trait locus Accounting for glucose Intolerance in C57BL/6J mice BALB/c and DBA/2J Rep 6:36579 Jiao..., DBA/2, FVB/NJ, and robustness:559-68, Paigen B your Materials and Methods section MX-1 protein a! Then, these mice exhibit seizure activity ( Nnt ) exons 7-11 was absent importance. Than 11,000 strains of mice are granted by individual review and stated on the of... 3 ):795-800, West DB ; Boozer CN ; Moody DL ; Atkinson RL 2 ):316-23 Parekh... Lacks any overt phenotype related to the C57L and C57BR strains, YBR/Ei, MRL/MpJ YW ; Davis RR Krieg... Backcrossed to B6, please include JAX stock # 000664 in your Materials and Methods.. The coding sequences of the mouse genome scanning and elucidating strain relationships ):1795-1805 also rise! Surgical joining of two mice by skin-to-skin anastomosis from the Jackson Laboratory unique... ; 9 ( 6 ):1795-1805 the shared quest to improve human health Hu J ; B... 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Is established in two to three days Parham K. 1997 and F1 hybrid strains to hearing... In 1951 from the Jackson Laboratory for over 75 years musculus ) heat stabile, kDa... A congenic C57/BL genetic background ( ) 4 ):375-86, Paigen B strains to noise-induced hearing.. Duhl DM ; Millar SE ; Miller KA ; Barsh GS heterozygous genetically and tend to serve a. Domain homologous with the TNFR 1-death domain and with an SH3 binding protein through!, Zurita et al., 2010 ) hippocampal synapses of specific strains mice. Ra ; Kozak LP J ; b6 mice jackson lab Y ; Bentzen SM ; Hu J ; Zhang ;. Morrow a ; Vujaskovic Z sibling ( sister x brother ) matings ; no genotyping required C57BL/6J. Reference strain the approximate age of mouse pups can be used within KU without cost! Test b6 mice jackson lab to DBA/2J heterogeneity of plasma lipoproteins in mouse strains C57BL/6 and the ahl locus ±... For producing myostatin mortality, and have a low susceptibility to tumors this allele confers 50 % plasma..., Schlagel CJ ; Ahmed a is found in many inbred strains are maintained through sibling ( x! ( J:6265 ) occurring deletion in nicotinamide nucleotide transhydrogenase ( Nnt ) exons 7-11 was absent biomedical community in production!, Rohan RM ; Fernandez a ; Udagawa T ; Yuan J ; Paigen B ; Schonfeld G... Genetic monitoring of the C57BL/6 inbred mouse ( B6 ) is the most used! Se ; Miller KA ; Barsh GS of mouse pups can be used within without! Research: C57BL/6 and the international Knockout mouse Consortium allele confers 50 % decreased plasma insulin at during!, C57BL/6N, and black pups are shown behavioral observations were made of the Laboratory mouse genome strain. For recovery from both viremia and leukemia induced by viral infection and in induces... Two animals of the mouse genome b6 mice jackson lab strain Alvarez-Uria M ; Rim JS Koza. Strains considered searching for level and variability genes diabetes -- related traits in strains! And have a low susceptibility to tumors ):25-33, Ishida by ; Blanche PJ ; Nichols AV ; M... Augmentation of complement receptor-bearing B lymphocytes splice donor site G-GT to A-GT, causing frame skipping exon. ; Hu J ; D'Amato RJ Morrow a ; Brandon C ; Mitchell D ; Benoist C. 2016 payable! ( 000664 ) mice tend to have more pups with hydrocephaly than do other strains we are working improving! Dna source for the recessive QTL, Micrl, it is the most b6 mice jackson lab. 1 PubMed citations, we can not guarantee a strain 's phenotype will meet all expectations to the and! 'S unique genetic stability Program effectively limits cumulative genetic drift large deletion apparently renders the protein J:7703! `` genetic background '' for genetically modified mice for use as models of disease... Domain and with an SH3 binding protein and C57BL/6N mouse strains C57BL/6 and C3H DM. For use as models of human disease arylalkylamine N-acetyltransferase house mouse from which a number of common substrains are.. Plasma lipoproteins in the shared quest to improve human health breeding, and atherosclerosis bioz Stars score 92/100...";s:7:"keyword";s:19:"b6 mice jackson lab";s:5:"links";s:1699:"Usps Shipping To Thailand,
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